Mikrokapsuliranje dronedaron hidroklorida

master's thesis

• Title (english): Microencapsulation of dronedarone hydrochloride
• Author: Marija Talajić
• Mentor: Gordana Matijašić (mentor)
• Committee member: Gordana Matijašić (predsjednik povjerenstva)
• Committee member: Krunoslav Žižek (član povjerenstva)
• Committee member: Igor Dejanović (član povjerenstva)
• Granter: University of Zagreb; Faculty of Chemical Engineering and Technology; Zagreb
• Defense date and country: 2017-07-05, Croatia
• Scientific / art field, discipline and subdiscipline: TECHNICAL SCIENCES; Chemical Engineering; Mechanical, Thermal and Separation Processes

Abstract

U posljednje vrijeme sve više raste interes za tehnikama mikrokapsuliranja, naročito u farmaceutskoj industriji. Jedan od glavnih razloga primjene mikrokapsuliranja je što mikrokapsule omogućuju kontrolirano otpuštanje lijeka. Kontrolirano otpuštanje može se postići tako da se djelatna tvar postepeno propušta kroz polimernu ovojnicu mikrokapsule. Na taj način omogućuje se isporuka optimalne količine lijeka u organizam, u određeno vrijeme. Cilj ovog istraživanja bio je proučiti različite tehnike dobivanja mikrokapsula i prirediti dozirni oblik lijeka koji će omogućiti produljeno otpuštanje. Kao djelatna tvar korišten je dronedaron hidroklorid, lijek koji služi za indikaciju srčane aritmije. Mikrokapsule su pripremane na dva načina, sušenjem raspršivanjem i koacervacijom, a kao polimeri za oblaganje korištene su arapska guma i želatina. Morfologija dobivenih kapsula ispitana je metodom pretražne elektronske mikroskopije. Kinetika otpuštanja dronedarona iz mikrokapsula ispitana je in vitro laboratorijskim ispitivanjima, a dobiveni profili otpuštanja opisani su pomoću odabranog matematičkog modela. Analizom dobivenih rezultata, utvrđeno je da su mikrokapsule uspješno dobivene postupkom sušenja raspršivanjem, korištenjem suspenzije kao pojne smjese. Mijenjanjem udjela polimera pokazalo se da su najbolji dobiveni rezultati dobiveni iz eksperimenata gdje je omjer polimera i djelatne tvari bio 1:1. Iz dobivenih mikrografija mogu se uočiti formirane mikrokapsule, a iz profila otpuštanja za te uzorke može se vidjeti da je postignuto kontrolirano otpuštanje lijeka.

Abstract (english)

Recently, there is a growing interest in using microencapsulation technologies, especially in the pharmaceutical industry. One of the main reasons for microencapsulation is that microcapsules allow controlled drug release. Controlled drug release can be achieved by gradual diffusion of active ingredient through the polymeric coating of the microcapsule. This way, it is possible to deliver the optimum amount of a medication to the body at a given time. The aim of this paper was to study the various microencapsulation techniques and to provide a dosage form that will ensure controlled release. Dronedarone hydrochloride, a medicine used to indicate cardiac arrhythmia, was used as an active substance. Microcapsules were prepared by spray drying and coacervation. Gum arabic and gelatin were used as coating polymers. The morphology of the obtained microcapsules was tested using the scanning electron microscopy. The dronedarone release profiles from the microcapsules were tested in vitroin laboratory tests, and the drug release kinetics was described using a selected mathematical model. Results showed that the microcapsules were successfully obtained from feed suspension by using spray drying. Ratio of polymer and DNR was varied and the best results were obtained from the experiments where the ratio was 1:1. From the obtained micrographs, it can be seen that microcapsules were formed. Dissolution profiles showed that a controlled release of the drug has been achieved.

• Keywords: mikrokapsuliranje; kontrolirano otpuštanje lijeka; sušenje raspršivanjem; koacervacija; dronedaron hidroklorid; arapska guma; želatina
• Keywords (english): microencapsulation; controlled drug release; spray drying; coacervation; dronedarone hydrochloride; gum arabic; gelatin
• Language: croatian
• URN:NBN: urn:nbn:hr:149:616422
• Study programme: Title: Chemical Engineering - Graduate study; Study programme type: university; Study level: graduate; Academic / professional title: magistar/magistra inženjer/inženjerka kemijskog inženjerstva (magistar/magistra inženjer/inženjerka kemijskog inženjerstva)
• Type of resource: Text
• File origin: Born digital
• Access conditions: Open access
• Created on: 2019-10-02 12:40:57