Sorpcija metoklopramida na prirodne uzorke tla i sedimente

undergraduate thesis

• Title (english): Sorption of metoclopramide on natural soil and sediment samples
• Author: Marieta Ćurković
• Mentor: Dragana Mutavdžić Pavlović (mentor)
• Committee member: Dragana Mutavdžić Pavlović (predsjednik povjerenstva)
• Committee member: Marijana Hranjec (član povjerenstva)
• Committee member: Martina Biošić (član povjerenstva)
• Granter: University of Zagreb; Faculty of Chemical Engineering and Technology; Zagreb
• Defense date and country: 2019-09-17, Croatia
• Scientific / art field, discipline and subdiscipline: NATURAL SCIENCES; Chemistry

Abstract

Metoklopramid je farmaceutik koji spada u skupinu antiemetika. Ima širok spektar kliničkih primjena u različitim područjima, pokazuje antiemetičko i prokinetičko djelovanje, a obično se koristi u prevenciji i za ublažavanje mučnina i povraćanja. Metoklopramid, kao i mnogi drugi farmaceutici, može štetno djelovati na okoliš. Proces koji govori o sudbini i transportu otpadnih farmaceutika naziva se sorpcija. Iz tog razloga se u ovom radu provodila sorpcija metoklopramida na prirodne uzorke tla i sedimenta koji su svi prikupljeni s područja Republike Hrvatske. Sorpcija je opisana pomoću Freundlichovih te Dubinin – Radushkevichevih modela izotermi, a pomoću njih su izračunati i parametri sorpcije. Također je ispitan i utjecaj ionske jakosti, utjecaj pH vrijednosti na proces sorpcije, kinetika kao i mehanizam sorpcije. Dobiveni rezultati su pokazali da se kapacitet sorpcije smanjuje porastom ionske jakosti i porastom pH vrijednosti te da pseudokinetički model II. reda najbolje opisuje brzinu sorpcije.

Abstract (english)

Metoclopramide is a pharmaceutical which falls in group of antiemetics. It has clinical uses in wide variety of fields, it shows antiemetic and prokinetic activity, and usually it is used in prevention and reduction of nausea and vomit. Metoclopramide just as many other pharmaceuticals can have bad consequences for environment. Process which tells about fate and transport of waste pharmaceuticals is called sorption. Because of that, in this experiment sorption of metoclopramides on soil, and sediment samples was spent, on samples which where all collected in Republic of Croatia. Sorption was described with Freundlich's and Dubinin-Radushkevich's models of isotherms and with that, all parameters of sorption were calculated. Effects of ionic strength, pH value effects, kinetics and mechanism of sorption were also examined. Collected results have shown that capacity of sorption decrease by the increase of ionic strength and pH values. It is concluded that pseudo second order model best describes kinetics of sorption.

• Keywords: metoklopramid; antiemetik; tlo; sediment; sorpcija; ionska jakost; pH
• Keywords (english): metoclopramide; antiemetic; soil; sediment; sorption; ionic strength; pH
• Language: croatian
• URN:NBN: urn:nbn:hr:149:934871
• Project: Number: IP-2014-09-2353; Title: Sudbina farmaceutika u okolišu i tijekom naprednih postupaka obrade voda; Title: Fate of pharmaceuticals in the environment and during advanced wastewater treatment; Acronym: PharmaFate; Leader: Sandra Babić; Jurisdiction: Croatia; Funder: HRZZ; Funding stream: IP
• Study programme: Title: Applied Chemistry - Undergraduate study; specializations in: Environmental chemistry and green technologies, Advanced materials and technologies, Applied organic chemistry; Course: Environmental chemistry and green technologies; Study programme type: university; Study level: undergraduate; Academic / professional title: sveučilišni/a prvostupnik/prvostupnica (baccalaureus/baccalaurea) primijenjene kemije (sveučilišni/a prvostupnik/prvostupnica (baccalaureus/baccalaurea) primijenjene kemije)
• Type of resource: Text
• File origin: Born digital
• Access conditions: Open access
• Created on: 2023-02-14 10:00:44