Faktorski plan pokusa i analiza varijance pri miješanju prašaka

undergraduate thesis

• Title (english): Factorial design and analysis of variance in powder blending
• Author: Ema Vukelić
• Mentor: Gordana Matijašić (mentor)
• Committee member: Gordana Matijašić (predsjednik povjerenstva)
• Committee member: Krunoslav Žižek (član povjerenstva)
• Committee member: Igor Dejanović (član povjerenstva)
• Granter: University of Zagreb; Faculty of Chemical Engineering and Technology; Zagreb
• Defense date and country: 2016-09-19, Croatia
• Scientific / art field, discipline and subdiscipline: TECHNICAL SCIENCES; Chemical Engineering; Mechanical, Thermal and Separation Processes

Abstract

Farmaceutske industrija ulaže u istraživanja usmjerena na izučavanje i optimiranje proizvodnje tableta i smanjenje troškova. Cilj je ovog rada utvrditi utjecaj brzine miješanja praškastih pripravaka i udjela magnezijeva stearata na kvalitetu tablete. Miješane su tri komponente: granulirana PanExcea, saharoza i magnezijev stearat. Plan pokusa je proveden pomoću programskog paketa Design-Expert® 6 (Stat-Ease Inc.). Napravljen je faktorski plan s dvije varijable na dvije razine, s dvije serije eksperimenata što je rezultiralo s osam eksperimenata. Kao odziv procesa odabrana je tvrdoća tableta i standardna devijacija mase tableta. Statistička značajnost svih čimbenika je osnovana analizom varijance (ANOVA) te su dobiveni modeli za procjenu tvrdoće tablete i standardne devijacije mase.

Abstract (english)

The pharmaceutical industry is investing in research focused on the optimization of tablets production and reducing costs. The aim of this study was to determine the impact of blending time and magnesium stearate content on the quality of tablets. Three components were mixed: granulated PanExcea, sucrose and magnesium stearate. The experiment was carried out using the Design-Expert® 6 software (Stat-Ease Inc.). The factorial design with two variables at two levels and two sets of experiments was constructed, which resulted in eight experiments. As a process response the tablet hardness and standard deviation of tablets weight were selected. The statistical significance of all factors was established using analysis of variance (ANOVA) and models for assessing the hardness of tablets and standard deviation of weight were obtained.

• Keywords: tablete; faktorski plan; analiza varijance; tvrdoća; standardna devijacija mase
• Keywords (english): tablets; factorial design; analysis of variance; hardness; standard deviation of weight
• Language: croatian
• URN:NBN: urn:nbn:hr:149:932151
• Study programme: Title: Materials Science and Engineering - Undergraduate study; Study programme type: university; Study level: undergraduate; Academic / professional title: sveučilišni/a prvostupnik/ prvostupnica (baccalaureus/baccalaurea) inženjer/inženjerka kemijskog inženjerstva (sveučilišni/a prvostupnik/ prvostupnica (baccalaureus/baccalaurea) inženjer/inženjerka kemijskog inženjerstva)
• Type of resource: Text
• File origin: Born digital
• Access conditions: Open access
• Created on: 2018-02-07 12:07:38