Minitablete: partikulski sustav za oralnu primjenu lijeka

undergraduate thesis

• Title (english): Mini-tablets: a particulate system for oral drug delivery
• Author: Bonita Jurec
• Mentor: Krunoslav Žižek (mentor)
• Committee member: Krunoslav Žižek (predsjednik povjerenstva)
• Committee member: Gordana Matijašić (član povjerenstva)
• Committee member: Irena Škorić (član povjerenstva)
• Granter: University of Zagreb; Faculty of Chemical Engineering and Technology; Zagreb
• Defense date and country: 2018-09-14, Croatia
• Scientific / art field, discipline and subdiscipline: TECHNICAL SCIENCES; Chemical Engineering; Mechanical, Thermal and Separation Processes

Abstract

Ovaj rad je sažet pregled razvoja i proizvodnje minitableta, višejediničnih sustava za oralnu primjenu lijeka. Farmaceutska industrija se u novije vrijeme okreće razvoju novih oblika koje koriste već postojeće djelatne tvari kako bi se razvio efikasniji i kvalitetniji lijek. Višejedinični dozirni oblici poput peleta, granula i minitableta u usporedbi s konvencionalnim monojediničnim oblicima, tabletama i kapsulama, imaju širi spektar primjene, smanjena je učestalost doziranja, a povećana učinkovitost djelatne tvari. Najpopularniji su danas višejedinični dozirni oblici s modificiranim otpuštanjem djelatne tvari. Od svih višejediničnih dozirnih oblika, minitablete se ističu u nekoliko segmenata od ostalih oblika pa im se zbog toga posljednjih nekoliko desetljeća pridaje sve veća pažnja. Na tržištu je dostupno oko dvadeset vrsta komercijalnih minitableta, a zbog iznimnih svojstava nastoji se povećati njihov broj. Minitablete se proizvode koristeći dobro poznatu i razvijenu tehniku tabletiranja, uz neke neophodne modifikacije. Oblažu se kao i konvencionalne tablete pa u tehnologiju oblaganja minitableta nije potrebno investirati mnogo. Mogu se puniti u kapsule ili prešati u tablete. Predstavljaju pogodan oblik doziranja za sve uzraste pa čak i za djecu te starije osobe za koje je vrsta doziranja uglavnom ograničavajući faktor pri odabiru lijeka.

Abstract (english)

This thesis is a concise overview of the development and production of mini-tablets, multiparticulate oral drug delivery systems. Pharmaceutical industry has recently put more effort in development of new dosage forms that use already existing active pharmaceutical ingredients to develop a more efficient and higher quality drug product. Multiple unit dosage forms such as pellets, granules and mini-tablets when compared with conventional single unit dosage forms like tablets and capsules own more flexibility in their use, reduced frequency of dosing and increased effectiveness of the drug. These days the most popular multiple unit dosage forms are modified drug release systems. Among all multiple unit dosage forms, mini-tablets arise in several segments when compared to others. Because of that, the interest in mini-tabs technology grows for the last few decades. There are about twenty commercially available mini-tab products and due to their great properties, there is an effort to increase their number. Mini-tablets are manufactured using a well-known and established tableting technique with some inevitable modifications. They are coated in the same way as conventional tablets so it is not necessary to invest a lot in coating technique. They can be filled into capsules or compressed into tablets. They are also a convenient dosage form for all ages, even for children and elderly people for whom the dosage form is a limiting factor in drug selection.

• Keywords: oralni dozirni oblici; monojedinični dozirni oblici; višejedinični dozirni oblici; minitablete; raspadljive minitablete za usta
• Keywords (english): oral dosage dorms; single unit dosage forms; multiple unit dosage forms; mini-tablets; orally disintegrating mini-tabs
• Language: croatian
• URN:NBN: urn:nbn:hr:149:831713
• Study programme: Title: Materials Science and Engineering - Undergraduate study; Study programme type: university; Study level: undergraduate; Academic / professional title: sveučilišni/a prvostupnik/ prvostupnica (baccalaureus/baccalaurea) inženjer/inženjerka kemijskog inženjerstva (sveučilišni/a prvostupnik/ prvostupnica (baccalaureus/baccalaurea) inženjer/inženjerka kemijskog inženjerstva)
• Type of resource: Text
• File origin: Born digital
• Access conditions: Open access
• Created on: 2022-05-09 12:12:19