Postupci dobivanja kokristala

undergraduate thesis

• Title (english): Co-crystals formation methods
• Author: Floren Radovanović - Perić
• Mentor: Jasna Prlić Kardum (mentor)
• Committee member: Jasna Prlić Kardum (predsjednik povjerenstva)
• Committee member: Mirela Leskovac (član povjerenstva)
• Committee member: Aleksandra Sander (član povjerenstva)
• Granter: University of Zagreb; Faculty of Chemical Engineering and Technology; Zagreb
• Defense date and country: 2018-09-19, Croatia
• Scientific / art field, discipline and subdiscipline: TECHNICAL SCIENCES; Chemical Engineering; Mechanical, Thermal and Separation Processes

Abstract

Farmaceutski kokristali se u zadnje vrijeme istražuju kao nova vrsta krutih lijekova sa poboljšanim fizikalno - kemijskim svojstvima. Interes pobuđuje činjenica, da se dobivanjem kokristala, povećava broj kristalnih oblika za već postojeće djelatne farmaceutske tvari. Također je važno naglasiti da na ovaj način farmaceutske tvrtke dobivaju mogućnost prijave nove patentne prijave i proboja na tržište s novim generičkim lijekom, ali i poboljšanje svojstva, kao što su: topljivost, stabilnost i bioraspoloživost, a koja su od velike važnosti za primjenu lijeka. U ovom radu istražen je modelni sustav za dobivanje kokristala: maleinska kiselina i kofein. Cilj rada bio je dobiti sve kokristalne forme maleinske kiseline i kofeina te istražiti utjecaj temperature, početne koncentracije komponenti u otopini i djelovanja ultrazvuka na konačnu faznu ravnotežu. Kokristali su identificirani rendgenskom difrakcijom te dodatno okarakterizirani diferencijalnom pretražnom kalorimetrijom i pregledom na elektronskom mikroskopu. Samo u jednom slučaju dobivena je čista forma, ali ukupni rezultati daju dobar uvid utjecaja ispitivanih parametara na mogućnosti dobivanja različitih kokristalnih oblika.

Abstract (english)

Pharmaceutical co-crystals have lately been explored as a class of solid phase drugs with enhanced physiochemical properties. The fact that awakens interest in co-crystals is that by preparing active pharmaceutical ingredients (API) by methods of co-crystallization increases the total number of possible crystal forms for already existing APIs. It is also important to note that these methods of API preparation open up new pathways and opportunities regarding intelectual property amongst pharmaceutical companies as well as help enhance their properties, such as: solubility, stability and bioavailability which are of great importance for drug application. In this study, a model system for creating co-crystals; maleic acid and caffeine, was tested. The aim of this study was to generate all existing co-crystal forms of maleic acid and caffeine as well as explore the effect of starting temperature, starting concentration of both components in the solution and ultrasound on the final phase equilibrium. Co-crystals were identified by X-ray diffraction, and characterized through differential scanning calorimetry (DSC) and scanning electron microscopy (SEM). Despite the fact that only one case a pure form was isolated, the rest of the results nevertheless gave very good insight regarding the effects of the studied parameters on the possibilities of preparing various co-crystal forms.

• Keywords: kokristalizacija; kofein i maleinska kiselina
• Keywords (english): co-crystallization; caffeine and maleic acid
• Language: croatian
• URN:NBN: urn:nbn:hr:149:039512
• Study programme: Title: Chemical Engineering - Undergraduate study; Study programme type: university; Study level: undergraduate; Academic / professional title: sveučilišni/a prvostupnik/ prvostupnica (baccalaureus/baccalaurea) inženjer/inženjerka kemijskog inženjerstva (sveučilišni/a prvostupnik/ prvostupnica (baccalaureus/baccalaurea) inženjer/inženjerka kemijskog inženjerstva)
• Type of resource: Text
• File origin: Born digital
• Access conditions: Open access
• Created on: 2022-05-20 12:52:37