Uloga polimera u povećanju topljivosti djelatne tvari

undergraduate thesis

• Title (english): The role of polymers in drug solubility enhancement
• Author: Eva Pančić
• Mentor: Krunoslav Žižek (mentor)
• Committee member: Krunoslav Žižek (predsjednik povjerenstva)
• Committee member: Irena Škorić (član povjerenstva)
• Committee member: Domagoj Vrsaljko (član povjerenstva)
• Granter: University of Zagreb; Faculty of Chemical Engineering and Technology; Zagreb
• Defense date and country: 2019-09-20, Croatia
• Scientific / art field, discipline and subdiscipline: TECHNICAL SCIENCES; Chemical Engineering

Abstract

Lurasidon-hidroklorid je djelatna tvar izrazito male topljivosti u vodenom mediju što otežava njegovu primjenu u liječenju psihičkih poremećaja. S ciljem povećanja njegove topljivosti, metodom isparavanja otapala pripravljene su čvrste disperzije djelatne tvari u matricama hidrofilnih polimera, poli(etilen-glikola) i poli(vinil-pirolidona). Dobivene čvrste disperzije karakterizirane su Fourier-transformiranom infracrvenom spektroskopijom. Određena je prividna topljivost lurasidon-hidroklorida u disperzijama i fizikalnim mješavinama oba polimera. Preliminarna solubilizacijska ispitivanja ukazuju na potencijal poli(etilen-glikola) i poli(vinil-pirolidona) u povećanju topljivosti lurasidon-hidroklorida.

Abstract (english)

Lurasidone hydrochloride is an active pharmaceutical ingredient with extremely low aqueous solubility that makes this drug difficult to use for the treatment of psychotic disorders. For the purpose of drug solubility enhancement, solid dispersions of a drug in matrices of hydrophilic polymers, poly(ethylene glycol) and poly(vinyl pyrrolidone), were prepared by solvent evaporation method. Derived solid dispersions were characterized by Fourier- transform infrared spectroscopy. The apparent solubility of lurasidone hydrochloride was detected in dispersions and physical mixtures with both polymers. Preliminary solubilisation tests indicate the potential of poly(ethylene glycol) and poly(vinyl pyrrolidone) to enhance the solubility of lurasidone hydrochloride.

• Keywords: lurasidon-hidroklorid; poboljšanje topljivosti lijeka; čvrsta disperzija; poli(etilen-glikol); poli(vinil-pirolidon); metoda isparavanja otapala; testovi topljivosti
• Keywords (english): lurasidone hydrochloride; drug solubility enhancement; solid dispersion; poly(ethylene glycol); poly(vinyl pyrrolidone); solvent evaporation method; solubility tests
• Language: croatian
• URN:NBN: urn:nbn:hr:149:179453
• Study programme: Title: Environmental Engineering - Undergraduate study; Study programme type: university; Study level: undergraduate; Academic / professional title: sveučilišni/a prvostupnik/ prvostupnica (baccalaureus/baccalaurea) inženjer/inženjerka ekoinženjerstva (sveučilišni/a prvostupnik/ prvostupnica (baccalaureus/baccalaurea) inženjer/inženjerka ekoinženjerstva)
• Type of resource: Text
• File origin: Born digital
• Access conditions: Open access
• Created on: 2023-05-26 10:11:26