Utjecaj oblika kristala na svojstva djelatne tvari

master's thesis

• Title (english): The influence of the crystal shape on the properties of the active pharmaceutical ingredient
• Author: Martina Ćurić
• Mentor: Jasna Prlić Kardum (mentor)
• Committee member: Jasna Prlić Kardum (predsjednik povjerenstva)
• Committee member: Aleksandra Sander (član povjerenstva)
• Committee member: Željka Ujević Andrijić (član povjerenstva)
• Granter: University of Zagreb; Faculty of Chemical Engineering and Technology; Zagreb
• Defense date and country: 2023-09-29, Croatia
• Scientific / art field, discipline and subdiscipline: TECHNICAL SCIENCES; Chemical Engineering

Abstract

Većina djelatnih tvari proizvodi se u krutom obliku te je kristalizacija od iznimnog značaja za farmaceutsku industriju. Jedna od metoda koja poboljšava granulometrijska svojstva kristala je sferična kristalizacija u kojoj nastaju sferični kristali što smanjuje broj koraka pri formulaciji lijeka. Svrha ovog rada bila je različitim procesima odrediti sustav otapala za provedbu sferične kristalizacije te ispitati utjecaj različitih hidrodinamičkih uvjeta na granulometrijska svojstva dobivenih kristala. Uvjeti za provedbu sferične kristalizacije određeni su za djelatnu tvar ceritinib koja se koristi u liječenju raka pluća nemalih stanica. Kao dio preliminarnih eksperimenata, za odabir kapljevine za premoštenje koristio se programski sustav Dynochem. Odabrani sustav sadrži otapalo THF, vodu koja se koristi kao antiotapalo, kapljevinu za premoštenje heptan i polimer PVP (polivinilpirolidon) kao dodatak. Kako bi se ispitao utjecaj procesnih uvjeta na granulometrijska svojstva dobivenih kristala, provedena je njihova karakterizacija tijekom procesa te nakon sušenja. Analiza granulometrijskih svojstava određena je raspodjelom veličine čestica koja je dobivena metodom laserske difrakcije, morfologija kristala ispitana je optičkim elektronskim mikroskopom, a njihova struktura metodom difrakcije rendgenskih zraka.

Abstract (english)

Most of the active substances are produced in solid form, and crystallization is extremely important for the pharmaceutical industry. One of the methods that improves the granulometric properties of crystals is spherical crystallization, in which spherical crystals are formed, which reduces the number of steps in drug formulation. The purpose of this work was to determine the solvent system for spherical crystallization using different processes and to examine the influence of different hydrodynamic conditions on the granulometric properties of the obtained crystals. The conditions for the implementation of spherical crystallization are determined for the active substance ceritinib, which is used in the treatment of non-small cell lung cancer. As part of the preliminary experiments, the Dynochem software system was used to select the bridging fluid. The chosen system contains the solvent THF, water used as an antisolvent, the bridging liquid heptane and the polymer PVP (polyvinylpyrrolidone) as an additive. In order to examine the influence of process conditions on the granulometric properties of the obtained crystals, their characterization was carried out during the process and after drying. The analysis of granulometric properties was determined by the particle size distribution obtained by the laser diffraction method, the morphology of the crystals was examined by an optical electron microscope, and their structure by the X-ray diffraction method.

• Keywords: sferična kristalizacija; ceritinib; granulometrijska svojstva; Dynochem
• Keywords (english): spherical crystallization; ceritinib; granulometric properties; Dynochem
• Language: croatian
• URN:NBN: urn:nbn:hr:149:151056
• Project: Number: KK.01.1.1.07.0017; Title: Napredno vođenje procesa kristalizacije; Title: Advanced Control of Crystallization Process; Acronym: CrystAPC; Leader: Nenad Bolf; Jurisdiction: Croatia; Funder: EK; Funding stream: EFRR
• Study programme: Title: Chemical Engineering - Graduate study; Study programme type: university; Study level: graduate; Academic / professional title: sveučilišni/a magistar/magistra inženjer/inženjerka kemijskog inženjerstva (sveučilišni/a magistar/magistra inženjer/inženjerka kemijskog inženjerstva)
• Type of resource: Text
• File origin: Born digital
• Access conditions: Open access
• Created on: 2023-11-24 14:25:56