Title Pregled održivih hidrogelova na bazi škroba Title (english) A review on sustainable starch-based hydrogels Author Marija Ana Kolak Mentor Vesna Ocelić Bulatović (mentor)Committee member Vesna Ocelić Bulatović (predsjednik povjerenstva)Committee member Dajana Kučić Grgić (član povjerenstva)Committee member Iva Movre Šapić (član povjerenstva)Granter University of Zagreb Defense date and country 2023-09-22, Croatia Scientific / art field, TECHNICAL SCIENCES Abstract Hidrogelovi su fizikalno ili kemijski umrežene makromolekule koje tvore trodimenzionalnu mrežu sposobnu zadržati vodu, bez raspadanja. Posjeduju dobra elastična svojstva, gotovo identična tkivu živog organizma. Široka uporaba hidrogelova na bazi škroba u industrijskim i ekološkim područjima primjene smatra se od primarne važnosti. Škrob pripada skupini polisaharida, izgrađen od jedinica glukoze koje su povezane u dva polimerna lanca- amilozu i amilopektin. Proizvodnja i uporaba škroba u svijetu u konstantnom je porastu zbog pozitivnih učinaka koji se ostvaruju njegovim dodavanjem pri proizvodnji različitih proizvoda. Polimliječna kiselina, PLA termoplastični je, biorazgradljiv polimer proizveden sintetski, polimerizacijom monomera mliječne kiseline ili dimera cikličkog laktida. Razgrađuje se hidrolizom osnovnih estera polimera. Ima brojne biomedicinske primjene, kao što su šavovi, stentovi, mediji za dijalizu i uređaji za isporuku lijekova. U ovom radu proveden je postupak umješavanja škroba u PLA matricu s ciljem priprave biorazgradljivih hidrogelova koji bi potencijalno imali primjenu kao matriksni sustavi za dostavu lijeka s produljenim oslobađanjem u farmaceutskoj industriji. Cilj je bio ispitati može li škrob koji je hidrofilan, a umješan u malim udjelima u PLA matricu potaknuti njeno jače bubrenje te posljedično ubrzati njenu kemijsku razgradnju kroz vrijeme. Eksperimentalni dio rada obuhvaćao je pripravu mješavina polilaktida s malim udjelom škroba (5-15 mas. %) i hidrogelova postupkom inverzije faza uzrokovane promjenom otapala N-metil pirolidona (NMP) (engl. solvent induced phase inversion). Provedena je karakterizacija hidrogelova koji su formirani u vodi te je praćen stupanj bubrenja kroz vremenski period od 14 dana. GPC (engl. Gel permeation chromatography) metodom je ispitano je li došlo do promjene molekulskih masa polilaktidne matrice kao posljedica hirdolitičke razgradnje. Iz rezultata dobivenih na temelju provedenih mjerenja vidljivo je da je najveći stupanj bubrenja postigao uzorak PLA+TPS/NMP (90:10).
Iz GPC rezultata ustanovljeno je da nije došlo do kemijske razgradnje polilaktidne matrice, neovisno o količini i o vrsti škroba koja je bila umiješana.
Abstract (english) Hydrogels are physically or chemically cross-linked macromolecules that form
a three-dimensional network capable of retaining water without disintegration. They have good elastic properties, almost identical to the tissue of a living organism. The widespread use of starch-based hydrogels in industrial and ecological fields of application is considered to be of primary importance. Starch belongs to the group of polysaccharides, built from glucose units connected in two polymer chains - amylose and amylopectin. The production and use of starch in the world is constantly increasing due to the positive effects achieved by its addition in the production of various products. Polylactic acid, PLA is a thermoplastic, biodegradable polymer produced synthetically, by polymerization of lactic acid monomers or cyclic lactide dimers. It is broken down by hydrolysis of basic polymer esters. It has numerous biomedical applications, such as sutures, stents, dialysis media, and drug delivery devices.
In this work, the process of mixing starch into the PLA matrix was carried out with the aim of preparing biodegradable hydrogels that could potentially be used as matrix systems for the delivery of drugs with prolonged release in the pharmaceutical industry. The aim was to test whether starch, which is hydrophilic and mixed in small proportions in the PLA matrix, can stimulate its stronger swelling and consequently accelerate its chemical decomposition over time. The experimental part of the work included the preparation of mixtures of polylactide with a small proportion of starch (5-15 wt. %) and hydrogels by the process of phase inversion caused by the change of solvent N-methyl pyrrolidone (NMP) (solvent induced phase inversion). Hydrogels formed in water were characterized and the degree of swelling was monitored over a period of 30 days. The GPC (Gel permeation chromatography) method was used to determine whether there was a change in the molecular weight of the polylactide matrix as a result of hydrolytic decomposition. From the results obtained on the basis of the measurements, it is evident that the highest degree of swelling was achieved by the sample PLA+TPS/NMP (90:10). From the GPC results, it was established that there was no chemical degradation of the polylactide matrix, regardless of the amount and type of starch that was mixed.
Keywords
škrob
PLA
mješavine
hidrogel
bubrenje
kemijska razgradnja
Keywords (english)
starch
PLA
blends
hydrogel
swelling
chemical degradation
Language croatian URN:NBN urn:nbn:hr:149:457468 Study programme Title: Materials Science and Engineering - Undergraduate study Type of resource Text File origin Born digital Access conditions Open access Terms of use Created on 2023-11-30 13:20:48
