Sinteza i izrada makroporozne bioaktivne keramike

undergraduate thesis

• Title (english): Synthesis and development of macroporous bioactive ceramics
• Author: Patricija Klanac
• Mentor: Vilko Mandić (mentor)
• Committee member: Vilko Mandić (predsjednik povjerenstva)
• Committee member: Fabio Faraguna (član povjerenstva)
• Committee member: Petar Kassal (član povjerenstva)
• Granter: University of Zagreb; Faculty of Chemical Engineering and Technology; Zagreb
• Defense date and country: 2023-09-22, Croatia
• Scientific / art field, discipline and subdiscipline: NATURAL SCIENCES; Chemistry

Abstract

Istraživanje novih materijala koji će poboljšati standarde ljudskih života je dovelo do spoznaje različitih funkcija korištenja kalcijevih fosfata, posebice hidroksiapatita (HA) i β-trikalcijevog fosfata (β-TCP). β-TCP pripada sintetički dobivenim bioaktivnim i resorptivnim biomaterijalima. Poznat je po svojim osteokonduktivnim i osteoinduktivnim svojstvima.
Oblik samog biomaterijala je važan za njegovu ugradnju in vivo. Tu se govori o poroznosti kojoj je svrha omogućavanje boljeg protoka krvi, staničnog razvoja i mehaničke čvrstoće novonastale kosti. U ovom radu je istražen jedan od načina sinteze β-TCP-a: sinteza u čvrstom stanju (engl. solid state synthesis). Cilj rada bio je dobiti čisti i makroporozni β-TCP oblikovanog metodom impregnacije polimerne pjene. Dobivena bioaktivna keramika se identificirala rendgenskom difrakcijom i infracrvenom apsorpcijskom spektrometrijom s Fourierovom transformacijom te dodatno okarakterizirala pregledom na elektronskom mikroskopu. U oba dva slučaja su dobiveni zadovoljavajući rezultati porozne biokeramike sastavljene od β-TCP-a sa malim tragovima pirofosfata.

Abstract (english)

The research of new materials that will improve the standards of human life has led to the realization and finding usage of different functions of calcium phosphates, especially hydroxyapatite (HA) and β-tricalcium phosphate (β-TCP). β-TCP belongs to synthetically obtained bioactive and resorptive biomaterials. It is known for its osteoconductive and osteoinductive properties. The shape of the biomaterial itself is important for its incorporation in vivo. Here we are talking about porosity, which purpose is to enable better blood flow, cellular development and mechanical strength of newly formed bone. In this study, one of the methods of β-TCP synthesis was scrutinized: solid state synthesis. The aim of the work was to obtain pure and macroporous β-TCP formed by the polymer foam impregnation method. The obtained bioactive ceramics were identified by X-ray diffraction and infrared absorption spectrometry with Fourier transformation and additionally characterized by examination on an electron microscope. In both cases, satisfactory results were obtained for porous bioceramics composed of β-TCP with small traces of pyrophosphate.

• Keywords: biomaterijali; kalcijevi fosfati; β-trikalcijev fosfat; biokeramika
• Keywords (english): biomaterials; calcium phosphates; β-tricalcium phosphate; bioceramics
• Language: croatian
• URN:NBN: urn:nbn:hr:149:236305
• Study programme: Title: Applied Chemistry - Undergraduate study; specializations in: Environmental chemistry and green technologies, Advanced materials and technologies, Applied organic chemistry; Course: Advanced materials and technologies; Study programme type: university; Study level: undergraduate; Academic / professional title: sveučilišni/a prvostupnik/prvostupnica (baccalaureus/baccalaurea) primijenjene kemije (sveučilišni/a prvostupnik/prvostupnica (baccalaureus/baccalaurea) primijenjene kemije)
• Type of resource: Text
• File origin: Born digital
• Access conditions: Open access
• Created on: 2023-11-30 14:43:55