Utjecaj polietilen-glikola na biokompatibilnost i mehanička svojstva PLA/PEG nosača za primjenu u tkivnom inženjerstvu

master's thesis

• Title (english): The influence of polyethylene glycol on the biocompatibility and mechanical properties of PLA/PEG carriers for use in tissue engineering
• Author: Karla Zmiša
• Mentor: Emi Govorčin Bajsić (mentor)
• Committee member: Emi Govorčin Bajsić (predsjednik povjerenstva)
• Committee member: Mirela Leskovac (član povjerenstva)
• Committee member: Ljerka Kratofil Krehula (član povjerenstva)
• Granter: University of Zagreb; Faculty of Chemical Engineering and Technology; Zagreb
• Defense date and country: 2023-11-30, Croatia
• Scientific / art field, discipline and subdiscipline: TECHNICAL SCIENCES; Chemical Engineering

Abstract

Sve većim razvojem tehnologije i generiranjem novih ideja danas se sve više radi na poboljšanju standarda života i produljenju životnog vijeka. U skladu s tim radi se na razvijanju biomaterijala, odnosno materijala koji mogu biti implementirani unutar ljudskog organizma kao medicinski uređaj ili implantat na način da zamijene ili potpomognu funkciju nekog organa. Tkivno inženjerstvo i proizvodnja funkcionalnih tkiva i organa dio su moderne biomedicinske znanosti. Ova grana primarno je fokusirana na zamjenu biomaterijala, koji se koriste za popravak ili zamjenu oštećenog tkiva s 3D nosačima pomoću kojih bi se moglo oštećeno tkivo obnoviti. Tijekom istraživanja provedenog za ovaj rad proučavane su polimerne mješavine polilaktida (PLA) i polietilen-glikola (PEG) kao PLA/PEG nosača. Izuzetno je važno da svaki materijal koji se koristi u medicini i dolazi u doticaj s određenim tkivom s istim bude biokompatibilan. Biokompatibilnost je sposobnost materijala da u dodiru sa živim tkivom ne izaziva oštećenje tkiva ili alergijske reakcije organizma. PLA ima odlična svojstva biokompatibilnosti i biorazgradivosti, a dodatkom PEG-a povećava se hidrofilnost, čime se utječe na bolju biorazgradivost PLA/PEG nosača. Toplinske tehnike kojima će se istražiti svojstva pripravljenih polimernih mješavina su diferencijalna pretražna kalorimetrija (DSC), termogravimetrijska analiza (TGA) kao i spektroskopska tehnika infracrvene spektroskopije s Fourierovom transformacijom (FTIR), te analiza kontaktnog kuta.

Abstract (english)

With the increasing development of technologies and the generation of new ideas, today more and more people want to work on improving the standard of living and extending life expectancy. Accordingly, a lot of work is being done on the development of biomaterials, that is, materials that can be implemented inside the human organism as a medical device or implant in such a way as to replace or support the function of an organ. Tissue engineering and the production of functional tissues and organs are part of modern biomedical science. This branch of biomedicine is primarily focused on replacing biomaterials, which are used to repair or replace damaged tissue, with 3D supports that could be used to reproduce the damaged tissue. During the research conducted for this work, polymer mixtures of polylactide (PLA) and polyethylene glycol (PEG) were studied as PLA/PEG scaffolds. It is extremely important that every material that is used in medicine and comes into contact with a specific tissue is biocompatible with it. Biocompatibility is the ability of a material not to cause tissue damage or allergic reactions of the organism in contact with living tissue. PLA has excellent biocompatibility and biodegradability properties, and the addition of PEG increases hydrophilicity, which affects the better biodegradability of the PLA/PEG scaffolds.
The thermal techniques used to investigate the properties of the prepared polymer blends are differential scanning calorimetry (DSC) and thermogravimetric analysis (TGA) as well as spectroscopic technique of infrared spectroscopy with Fourier transformation (FTIR) and contact angle.

• Keywords: PLA; PEG; polimerne mješavine; tkivno inženjerstvo; PLA/PEG nosač; biokompatibilnost
• Keywords (english): PLA; PEG; polymer blends; tissue engineering; PLA/PEG scaffolds; biocompatibility
• Language: croatian
• URN:NBN: urn:nbn:hr:149:038268
• Study programme: Title: Materials Science and Engineering - Graduate study; Study programme type: university; Study level: graduate; Academic / professional title: sveučilišni/a magistar/magistra inženjer/inženjerka kemijskog inženjerstva (sveučilišni/a magistar/magistra inženjer/inženjerka kemijskog inženjerstva)
• Type of resource: Text
• File origin: Born digital
• Access conditions: Open access
• Created on: 2023-12-11 14:42:22