Kinetika oksidacije N-Cbz-3-amino-1,2-propandiola katalizirane s alkohol dehidrogenazom iz konjske jetre

undergraduate thesis

• Title (english): Kinetics of oxidation of N-Cbz-3-amino-1,2-propanediol catalyzed by horse liver ADH
• Author: Dino Skendrović
• Mentor: Zvjezdana Findrik Blažević (mentor)
• Committee member: Zvjezdana Findrik Blažević (predsjednik povjerenstva)
• Committee member: Martina Sudar (član povjerenstva)
• Committee member: Marija Vuković Domanovac (član povjerenstva)
• Granter: University of Zagreb; Faculty of Chemical Engineering and Technology; Zagreb
• Defense date and country: 2016-09-12, Croatia
• Scientific / art field, discipline and subdiscipline: TECHNICAL SCIENCES; Chemical Engineering; Reaction Engineering

Abstract

U ovom radu opisana je kemijska i enzimatska oksidacija aminoalkohola Cbz-N-3-amino-1,2-propandiola. Kemijska oksidacija provedena je uz pomoć jodoksibenzojeve kiseline, a enzimatska uz alkohol dehidrogenazu iz konjske jetre. Provedena je je Cbz-zaštita aminokiseline kako bi se dokazalo da je ona nusprodukt navedenih metoda oksidacije. Određena je i kinetika reakcije oksidacije aminoalkohola katalizirana s alkohol dehidrogenazom iz konjske jetre te su procijenjeni kinetički parametri na temelju Michaelis-Menteničinog modela.

Abstract (english)

Chemical and enzymatic oxidation of the amino alcohol Cbz-N-3-amino-1,2-propandiol is described in this work. Chemical oxidation was carried out by iodoxybenzoic acid and enzymatic oxidation by horse liver alcohol dehydrogenase. Cbz-protection of amino acid was carried out to prove its existence as by-product of our oxidation methods. Kinetics of the amino alcohol oxidation catalyzed by horse liver alcohol dehydrogenase was determined and the kinetics parameters were estimated with Michaelis-Menten model.

• Keywords: kemijska oksidacija; enzimatska oksidacija; enzim; aminoalkohol; aldehid; Cbz zaštita
• Keywords (english): chemical oxidation; enzymatic oxidation; enzyme; amino alcohol; aldehyde; Cbz protection
• Language: croatian
• URN:NBN: urn:nbn:hr:149:220357
• Study programme: Title: Environmental Engineering - Undergraduate study; Study programme type: university; Study level: undergraduate; Academic / professional title: sveučilišni/a prvostupnik/ prvostupnica (baccalaureus/baccalaurea) inženjer/inženjerka ekoinženjerstva (sveučilišni/a prvostupnik/ prvostupnica (baccalaureus/baccalaurea) inženjer/inženjerka ekoinženjerstva)
• Type of resource: Text
• File origin: Born digital
• Access conditions: Open access
• Created on: 2018-02-05 08:59:54